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Centre de Référence des Rhumatismes Inflammatoires et Maladies Autoimmunes Systémiques Rares de l’Enfant (RAISE) / 2017
68
P,
et
al.
methotrexate
Leflunomide
or
juvenile
for
rheumatoid
arthritis.

N

Engl

J
Med.
2005
21;352(16):1655–66.
Apr
Silverman E, Spiegel L, Hawkins
D,
Petty
R,
Goldsmith
D,
Schanberg
L,

et

al.

Long-term
open-label
preliminary

study

of
the
safety
leflunomide
and
efficacy
of
in
patients

with
polyarticular-course
juvenile
Arthritis
rheumatoid
arthritis.
Rheum.
2005

Feb;52(2):554–
62.
Van
Rossum
MAJ,
Boers
van
M,
Soesbergen
RM,
Zwinderman
AH,

Fiselier

TJW,
Franssen
MJAM,

et

al.

Long-
term
outcome
of
juvenile
idiopathic
arthritis

following
a
trial:
early
Ann
2007
placebo-controlled
sustained
benefits
of
treatment.
Dis.
sulfasalazine
Rheum
Nov;66(11):1518–24.
Verbsky JW, White AJ. Effective
use
of
the
recombinant
interleukin 1 receptor antagonist
anakinra
systemic
in
therapy
resistant
onset
juvenile
rheumatoid
Rheumatol.
arthritis.
J
2004
Oct;31(10):2071–5.
Vojvodich
Andersson
Hagelberg
PF,
U,
Hansen
Sävendahl
JB,
L,
Etanercept
S.
treatment
improves

longitudinal
growth
in

prepubertal

children
with
juvenile

idiopathic

arthritis.
J
Rheumatol.
Dec;34(12):2481–5.
2007
Woo P, Wilkinson N, Prieur A-M,
Southwood
T,
Leone
V,
Livermore
P,
label
et
al.
Open
trial
phase

II
of

single,
ascending
doses

of

MRA

in
Caucasian
children
with
juvenile
severe
systemic
idiopathic
arthritis:

proof

of
principle of the efficacy of IL-
6
receptor

blockade

in

this
type
of
arthritis
and
demonstration
of

prolonged
clinical improvement. Arthritis
Res
Ther.

2005;7(6):R1281-
1288.
Wulffraat
NM,

Brinkman

D,
Ferster
A,

Opperman

J,

ten
Cate R, Wedderburn L, et al.
Long-term
autologous
follow-up
stem
of
cell
transplantation
for

refractory
juvenile
idiopathic
arthritis.
Transplant.
Bone
Marrow
2003 Aug;32 Suppl 1:S61-64.
Yokota
S,

Imagawa

T,

Mori
M,
Miyamae

T,

Aihara

Y,
Takei
S,

et

al.

Efficacy

and
safety
of
tocilizumab
in
patients
with

systemic-onset
juvenile
idiopathic

arthritis:

a
randomised,
double-blind,
placebo-controlled,
withdrawal
Lancet.
phase
2008
III
trial.
Mar
22;371(9617):998–1006.
Yokota
Imagawa
S,
T,
Miyamae
Iwata
T,
N,
Katakura
S,

Mori

M,

et

al.
Therapeutic
efficacy
of
humanized
recombinant

anti-
interleukin-6
receptor
antibody
in
children
with
juvenile
systemic-onset
idiopathic
arthritis.

Arthritis
Rheum. 2005 Mar;52(3):818–
25.
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